George L Scheffer Selected Research

major vault protein

5/2004	Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy.
11/2003	Major vault protein, a marker of drug resistance, is upregulated in refractory epilepsy.
10/2003	Expression of multidrug resistance proteins P-glycoprotein, multidrug resistance protein 1, breast cancer resistance protein and lung resistance related protein in locally advanced bladder cancer treated with neoadjuvant chemotherapy: biological and clinical implications.
9/2003	Overexpression of the human major vault protein in gangliogliomas.
2/2003	Molecular determinants of treatment response in human germ cell tumors.
12/2002	Disruption of the murine major vault protein (MVP/LRP) gene does not induce hypersensitivity to cytostatics.

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George L Scheffer Research Topics

Disease

28	Breast Neoplasms (Breast Cancer) 11/2012 - 04/2002
22	Neoplasms (Cancer) 01/2021 - 02/2002
6	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 02/2016 - 05/2002
3	Multiple Myeloma 01/2021 - 09/2008
3	Rheumatoid Arthritis 04/2012 - 02/2006
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 02/2011 - 11/2003
3	Carcinoma (Carcinomatosis) 03/2003 - 07/2002
2	Colorectal Neoplasms (Colorectal Cancer) 12/2017 - 05/2004
2	Inflammation (Inflammations) 02/2016 - 11/2009
2	Lung Neoplasms (Lung Cancer) 01/2014 - 07/2002
2	Autoimmune Diseases (Autoimmune Disease) 01/2013 - 11/2009
2	Neoplasm Metastasis (Metastasis) 11/2012 - 05/2004
2	Non-alcoholic Fatty Liver Disease 09/2012 - 12/2011
2	Colonic Neoplasms (Colon Cancer) 10/2008 - 05/2004
2	Epilepsy (Aura) 06/2005 - 11/2003
2	Hippocampal Sclerosis 05/2004 - 11/2003
2	Drug Resistant Epilepsy 11/2003 - 09/2003
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2021
1	Adenoma (Adenomas) 12/2017
1	Latent Infection 02/2016
1	Myeloid Leukemia (Leukemia, Myelocytic) 02/2016
1	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 01/2013
1	Disease Progression 12/2011
1	Diarrhea 02/2011
1	Prostatic Neoplasms (Prostate Cancer) 09/2008
1	Acute Kidney Injury (Acute Renal Failure) 09/2008
1	Necrosis 09/2008
1	Obesity 01/2008
1	Acute Liver Failure (Fulminant Hepatic Failure) 10/2007
1	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 10/2007
1	Liver Failure 10/2007

Drug/Important Bio-Agent (IBA)

34	Proteins (Proteins, Gene)FDA Link 12/2017 - 04/2002
19	Pharmaceutical PreparationsIBA 02/2016 - 02/2002
13	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 04/2012 - 02/2002
11	multidrug resistance-associated protein 1IBA 08/2010 - 03/2003
10	Adenosine Triphosphate (ATP)IBA 11/2012 - 06/2002
10	Multidrug Resistance-Associated ProteinsIBA 04/2012 - 12/2002
10	ATP-Binding Cassette Transporters (ABC Transporters)IBA 02/2012 - 07/2002
9	Messenger RNA (mRNA)IBA 12/2011 - 04/2002
6	major vault proteinIBA 05/2004 - 12/2002
5	Cytostatic AgentsIBA 02/2012 - 05/2002
5	Folic Acid (Vitamin M)FDA LinkGeneric 03/2009 - 03/2003
5	Mitoxantrone (Novantrone)FDA LinkGeneric 01/2007 - 11/2003
3	DNA (Deoxyribonucleic Acid)IBA 02/2016 - 10/2007
3	Bortezomib (Velcade)FDA Link 01/2013 - 09/2008
3	Proteasome InhibitorsIBA 01/2013 - 09/2008
3	Carrier Proteins (Binding Protein)IBA 12/2011 - 07/2002
3	Methotrexate (Mexate)FDA LinkGeneric 03/2009 - 06/2004
2	EnzymesIBA 02/2016 - 01/2008
2	XenobioticsIBA 09/2012 - 09/2008
2	CytokinesIBA 02/2012 - 07/2011
2	Member 2 Subfamily G ATP Binding Cassette TransporterIBA 01/2012 - 02/2011
2	Peptides (Polypeptides)IBA 09/2008 - 02/2006
2	Subfamily B ATP Binding Cassette TransporterIBA 09/2008 - 10/2003
2	Cisplatin (Platino)FDA LinkGeneric 09/2008 - 02/2003
2	Acetaminophen (Paracetamol)FDA LinkGeneric 10/2007 - 02/2006
2	Topotecan (Hycamtin)FDA LinkGeneric 01/2007 - 11/2003
2	Green Fluorescent ProteinsIBA 02/2006 - 11/2003
2	Phenobarbital (Luminal)FDA Link 06/2005 - 01/2002
2	Irinotecan (Camptosar)FDA LinkGeneric 04/2005 - 05/2004
2	Antineoplastic Agents (Antineoplastics)IBA 10/2004 - 10/2003
2	Complementary DNA (cDNA)IBA 10/2003 - 07/2002
2	Biological ProductsIBA 10/2003 - 01/2002
1	Hemoglobins (Hemoglobin)IBA 12/2017
1	Biomarkers (Surrogate Marker)IBA 12/2017
1	Complement System Proteins (Complement)IBA 12/2017
1	ProdrugsIBA 02/2016
1	RNA (Ribonucleic Acid)IBA 02/2016
1	Carboxylic Ester HydrolasesIBA 02/2016
1	AminopeptidasesIBA 02/2016
1	Epstein-Barr virus encoded RNA 1IBA 02/2016
1	MicroRNAs (MicroRNA)IBA 02/2016
1	Carboxylesterase (Hydrolase S)IBA 02/2016
1	EsterasesIBA 02/2016
1	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA 01/2014
1	Rituximab (Mabthera)FDA Link 01/2013
1	Conditioned Culture MediaIBA 11/2012
1	ArsenicIBA 09/2012
1	Antirheumatic Agents (DMARD)IBA 04/2012
1	carfilzomibIBA 04/2012
1	AnthraquinonesIBA 02/2012
1	Uric Acid (Urate)IBA 01/2012
1	Telomerase (Telomerase Reverse Transcriptase)IBA 07/2011
1	Gefitinib (Iressa)FDA Link 02/2011
1	Ritonavir (Norvir)FDA Link 08/2010
1	Lopinavir FDA Link 08/2010
1	Atazanavir Sulfate (Reyataz)FDA Link 08/2010
1	Leflunomide (Arava)FDA LinkGeneric 03/2009
1	Leucovorin (Folinic Acid)FDA Link 10/2008
1	AndrogensIBA 09/2008
1	Testosterone (Sustanon)FDA Link 09/2008
1	AnionsIBA 09/2008
1	CationsIBA 09/2008
1	dimethylethylsilylimidazoleIBA 01/2008
1	7-hydroxymethotrexateIBA 01/2007

Therapy/Procedure

4	Therapeutics 01/2021 - 04/2002
4	Drug Therapy (Chemotherapy) 05/2004 - 07/2002
1	Lasers (Laser) 11/2012
1	Immunotherapy 02/2012
1	Prostatectomy (Retropubic Prostatectomy) 09/2008